S
- S.C.A.R.S.
- S.C.S. Dangerous Waters
- S.T.A.L.K.E.R. Call of Pripyat
- S.T.A.L.K.E.R.: Clear Sky
- S.T.A.L.K.E.R.: Shadow of Chernobyl
- S.W.I.N.E.
- Sabre Ace: Conflict Over Korea
- Sacred
- Sacred 2: Fallen Angel
- Sacred: Underworld
- Sacrifice
- Safecracker (2000)
- Safecracker: The Ultimate Puzzle Adventure
- Saga
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- Saints Row 2
- Saints Row: The Third
- Saints Row: The Third - Genki Bowl VII
- Salammbo: Battle of Carthage
- Salt Lake 2002
- Salvo!
- Sam & Max Episode 101: Culture Shock
- Sam & Max Episode 102: Situation: Comedy
- Sam & Max Episode 103: The Mole, the Mob and the Meatball
- Sam & Max Episode 104: Abe Lincoln Must Die!
- Sam & Max Episode 105: Reality 2.0
- Sam & Max Episode 106: Bright Side of the Moon
- Sam & Max Episode 201: Ice Station Santa
- Sam & Max Episode 202: Moai Better Blues
- Sam & Max Episode 203: Night of the Raving Dead
- Sam & Max Episode 204: Chariots of the Dogs
- Sam & Max Episode 205: What's New, Beelzebub?
- Sam & Max: The Devil's Playhouse - Episode 1: The Penal Zone
- Sam & Max: The Devil's Playhouse - Episode 2: The Tomb of Sammun-Mak
- Sam & Max: The Devil's Playhouse - Episode 3: They Stole Max's Brain!
- Sam & Max Hit the Road
- Sam & Max: Season One -- Episode #1: Culture Shock
- Sam & Max: Season Two
- Sam & Max: The Devil's Playhouse
- Sam & Max: The Devil's Playhouse -- Episode 1: The Penal Zone
- Sam & Max: The Devil's Playhouse -- Episode 2: The Tomb of Sammun-Mak
- Sammy Sosa High Heat Baseball 2001
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- Sanctum (2011)
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- Sanity: Aiken's Artifact
- Santa Fe Mysteries: The Elk Moon Murder
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- Saw
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- Schizm
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- Sci-Fi Channel Trivia Game
- Scooter Physics Pro
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- Scrapland
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- Screamer
- Scud: Industrial Evolution
- Sea Dogs
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- Season Ticket Basketball 2003
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- SeaWorld Adventure Parks Tycoon
- SeaWorld Adventure Parks Tycoon 2
- Sebastian's Treasure Hunt
- Second Sight
- Secret Files: Tunguska
- Secret Service
- Secret Service: In Harm's Way
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- Secret Weapons Over Normandy
- Secret Wives' Club
- Secrets of the Ark: A Broken Sword Game
- Section 8
- Section 8: Prejudice
- Section 8: Prejudice - Overdrive Map Pack
- SEGA GT
- SEGA Rally Championship
- Sega Rally Championship 2
- SEGA Rally Revo
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- Sensei 2
- Sentient
- Septerra Core: Legacy of the Creator
- Sequence
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- Serious Sam Double D XXL
- Serious Sam HD
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- Serious Sam II
- Serious Sam: Double D
- Serious Sam: The First Encounter
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- Seven Games of the Soul
- Seven Kingdoms II: The Fryhtan Wars
- Seven Kingdoms: Conquest
- Shade: Wrath of Angels
- Shadoan
- Shadow Company: Left for Dead
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- Shadow Man
- Shadow of Destiny
- Shadow Ops: Red Mercury
- Shadow Warrior
- Shadow Watch
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- Shadowcaster
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- Shank
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- Shattered Galaxy
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- Sheep
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- ShellShock: Nam '67
- ShellShock: Nam '67
- Sherlock Holmes Versus Jack the Ripper
- Sherlock Holmes vs. Jack the Ripper
- Sherlock Holmes: Nemesis
- Sherlock Holmes: The Awakened
- Sherlock Holmes: The Silver Earring
- Shift 2 Unleashed
- Shin Megami Tensei Online: Imagine
- Ship Simulator 2008: New Horizons
- Shipwreckers!
- Shivers
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- Shogo: Mobile Armor Division
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- Shot-Online
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- Sid Meier's Alien Crossfire
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- Simon the Sorcerer: Who'd Even Want Contact?!
- SimPark
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- SiN
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- Sin Mission Pack: Wages of Sin
- Sinbad: Legend of the Seven Seas
- Singles 2: Triple Trouble
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- Skater Physics Pro (Android)
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- Spellbinder: The Nexus Conflict
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- SpellForce 2: Dragon Storm
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- SpellForce: Shadow of the Phoenix
- SpellForce: The Breath of Winter
- SpellForce: The Order of Dawn
- Spells of Gold
- Sphera: The Inner Journey
- Spider-Man
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- SpongeBob SquarePants: Employee of the Month
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- SpongeBob SquarePants: Operation Krabby Patty
- SpongeBob SquarePants: The Battle For Bikini Bottom
- SpongeBob SquarePants: The Krusty Collection
- Spore
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- Stacking
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- Star Wars Math: Jabba's Game Galaxy
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- Star Wars: Episode I: Racer
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- Star Wars: The Best of PC
- Star Wars: The Clone Wars - Republic Heroes
- Star Wars: The Force Unleashed - Ultimate Sith Edition
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- Star Wars: The Force Unleashed II
- Star Wars: The Gungan Frontier
- Star Wars: The Old Republic
- Star Wars: The Old Republic (Collector's Edition)
- Star Wars: TIE Fighter
- Star Wars: TIE Fighter (Collector's CD-ROM Edition)
- Star Wars: X-Wing -- Collector Series
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- Star Wars: Yoda Stories
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- Steel Panthers III: Brigade Command 1939-1999
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- Steel Panthers: World War 2 (Enhanded CD Edition)
- Steel Saviour
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- Steel Storm: Burning Retribution
- Steer Madness
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- Stolen
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- StoneAge 2
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- Storm of War: Battle of Britain
- Storm Over the Pacific
- Storm Riders Online
- Storm: Frontline Nation
- Stormrise
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- Stranger
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- Stratego
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- Stray Souls: Dollhouse Story
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- Streets of Rage 2
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- Supreme Ruler 2010
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- Swords & Soldiers HD
- Syberia II
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